Usage instructions:
Dosage and directions for use: Disprin regular strength 300mg: Adults: 1-3 tablets. Repeat 4 hourly if necessary but not more than 12 tablets during any 24 hour period. Children over 12 years: 1-2 tablets not more than four times a day, to a maximum of 10 tablets in 24 hours. Disprin regular strength 300mg can be dissolved in water, or if preferred, on the tongue. Disprin extra strength 500mg: Adults: 1-2 tablets. Children over 12 years: 1 tablet. Repeat 4 hourly if necessary but not more than 8 tablets during any 24 hour period, but if symptoms persist consult your doctor. In chronic rheumatic disease, 1-2 tablets every 4 hours over long periods. In acute rheumatism, 2-4 tablets four times daily. Disprin extra strength 500mg should be dissolved in water before being taken. If symptoms persist, consult your doctor. Do not use continuously for more than 10 days without consulting your doctor.

Storage instructions:
Storage directions: store below 25 degrees C in a dry place, out of reach of children.

Warnings:
Contra-indications: Patients with peptic ulcers, haemophilia or intolerance (hypersensitivity) to aspirin, severe renal impairment and patients receiving oral anticoagulant therapy. Aspirin should not be taken during the first and third trimesters of pregnancy and during lactation. Not to be used in children under the age of 12 years. Do not use continuously for more than 10 days without consulting your doctor. Aspirin has been implicated in Reye's syndrome, a rare but serious illness, in children and teenagers with chickenpox and influenza. A doctor should be consulted before aspirin is used in such patients. Side effects and special precautions: Dizziness, irritation of the gastric mucosa and resultant dyspepsia, haematemesis, and melaena may occur in some cases. Concomitant therapy with other gastric irritants, such as non-steroidal anti-inflammatory agents may increase the risk of gastric irritation. Disprin regular strength 300mg and Disprin extra strength 500mg should be withdrawn one week before surgery because of the possibility of increasing the bleeding times. Aspirin may cause allergic reactions, more commonly in asthmatics. Some persons, especially asthmatics, exhibit notable sensitivity to aspirin which may provoke various hypersensitivity reactions which may include skin eruptions, paroxysmal bronchospasm and dyspnoea. Aspirin should be administered with caution to patients with impaired renal function, dyspepsia, anaemia and when the patient is dehydrated. Aspirin has been implicated in Reye's syndrome, a rare but serious illness in children and teenagers with chickenpox and influenza. A doctor should be consulted before aspirin is used in such patients. Aspirin may enhance the activity of coumarin anticoagulants, methotrexate and oral anti-diabetic preparations and sulphonamides. Aspirin diminishes the effect of anti-gout preparations such as probenecid and sulphinpyrazone. Barbiturates and other sedatives may mask the respiratory symptoms of aspirin overdosage and have been reported to enhance its toxicity. Prolonged use of high doses may lead to anaemia, blood dyscrasias, gastro-intestinal haemorrhage, peptic ulceration and renal papillary necrosis. Interference with laboratory tests: Salicylates may produce falsely increased results for blood creatinine, urate (low dose aspirin) and urea. Falsely decreased results may be obtained for blood thyroxine and urate (>4g/day aspirin) and for urinary 5-HIAA (with nitrosonaphthol method). Urinary VMA (HMMA) levels may be falsely-increased or decreased depending on the method of analysis. Urinary glucose oxidase: aspirin may cause a false negative test in the presence of glycosuria. Known symptoms of overdosage and particulars of its treatment: These include dizziness, tinnitus, sweating, nausea, vomiting, altered glucose metabolism, mental confusion, hyperventilation, respiratory alkalosis, metabolic acidosis, ketosis, fluid and electrolyte losses. Depression of the central nervous system may lead to coma, cardiovascular collapse and respiratory failure. In children serious signs of overdosage may develop rapidly. In cases of overdosage, consult a doctor immediately. Treatment is symptomatic and supportive: the serum salicylate levels should be monitored closely and forced alkaline diuresis instituted if appropriate. Gastric lavage, restoration of fluid, electrolyte and acid balance, dialysis and supportive therapy may be required. Keep all medicines out of reach of children. Do not use continuously for more than 10 days without consulting your doctor. Please see enclosed package insert for indications and dosage.

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