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Duphalac

Lactulose Crystalline Powder 30 Sachets

Duphalac Lactulose Crystalline Powder 30 Sachets is no regular laxative. It helps to retain water in the colon, softening faeces and ensuring that normal colonic peristalsis occurs to help the body naturally and easily expel waste.

R 16900
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Description:
Abbott Duphalac Crystalline Powder 30 Sachets

Detailed Description:
Symptomatic treatment of constipation:1 sachet contains 10 g lactulose.< 0.25 g galactose.< 0.2 g lactose.Scheduling status.Proprietary name (and dosage form).Duphalac® dry.Crystalline powder.Composition:10 g of Duphalac Dry contains 10 g lactulose (4-0-β-D-galactopyranosyl-D-fructofuranose) (a maximum of 0.25 g galactose and 0.2 g lactose).Pharmacological classification:A. 11 5 Laxatives.Pharmacological action:Duphalac is a synthetic disaccharide of fructose and galactose, which is not split into its monosaccharide constituents in the small intestine due to the lack of a specific enzyme.It reaches the colon unchanged where it is broken down by the saccharolytic flora into organic acids, such as lactic acid and acetic acid - acids formed in the colon under physiological conditions. Due to this local osmotic effect in the colon, water is retained, the faecal mass softened and normal colonic peristalsis restored. The mode of action differs from that of conventional laxatives.In portal systemic encephalopathy administration of large doses of Duphalac results in a significant reduction in the pH of the colonic contents. Lowering the pH promotes conversion of non--ionised ammonia into ionised form. The latter form, being non-absorbable, leads to reduction of absorption of ammonia from the intestine into the portal circulation and may even promote the excretion of ammonia from the circulation into the faeces.In addition, the enhanced growth of saccharolytic bacteria results in a decreased formation of ammonia.Duphalac cannot be hydrolysed in the intestine; thus very little absorption occurs. Small amounts of non-hydrolised lactulose may be absorbed, but these are readily excreted via the kidneys.Indications:(a) Constipation:Particularly when associated with laxative habituation or for those patients in whom constipation presents a special problem, e.g. children, obstetric and postsurgical patients.(b) Portal systemic encephalopathy: Hepatic coma or pre-coma stages where hyperammonaemia is present.Contra-indications:Galactosaemia, including patients on a galactose-free diet. Patients with intestinal obstruction.Identification:A white to slightly yellow-coloured crystalline powder.Presentation:Packs of 10 or 30 sachets of 10 g lactulose.Registration number:28/11.5/0427.Date of publication of this package insert:27 May 1994.

Pack size:
30 sachets

Quantity in pack:
30

Marketing description:
Duphalac dry.Lactulose 10 g crystalline powder.Naturally restores intestinal balance.30 sachets.Abbott.

Brand:
Duphalac

Package type:
Box

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Usage instructions:
Dosage and directions for use:(a) Constipation:The dosage for constipation can be varied according to the individual response, but the following serves as a guide.Starting dose (3 days) - Maintenance dose.Gram per day - gram per day:Adults: 10-30 g - 10-20 g.Children 7-14 years: 10 g - 10 g.Children 1-6 years: 5-10 g - 5-10 g.If there is no response within 48 hours the dosage can be increased and if diarrhoea occurs the dosage should be decreased.Since Duphalac dry exerts its effect when it reaches the colon it may take 1-2 days before normal defaecation occurs.(b) Portal systemic encephalopathy:Starting dose 20-35 g three times a day. Maintenance dose has to be adjusted to the individual response.Duphalac dry can be best taken with breakfast cereals, or drinks such as tea, coffee, fruit juice or milk.

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