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Skinoren

Acne Gel 30g

Skinoren Gel 30g contains active ingredients including AzelaicAcid.

R 27000

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Clicks - pharmacy collection
pharmacy collection

This product is available for collection at a Clicks pharmacy only.

Clicks - dispensed by pharmacist
dispensed by pharmacist

Dispensed at the professional discretion of a Clicks Pharmicist

Otc Product Info

Description:
Skinoren Gel 30g

Detailed Description:
1g contains:0.15g micronised azelaic acid.0.1% (m/m) benzoic acid.Scheduling status:Proprietary name and dosage form:Skinoren gel.Composition:1g Skinoren gel contains 150 mg azelaic acid. Excipients: propylene glycol, polysorbate 80, lecithin, carbopol 980, triglycerides: medium chain, sodium hydroxide, disodium edetate, benzoic acid and purified water.Pharmacological classification:A 13.12 acne preparations.Pharmacological action:Pharmacodynamic properties:The antimicrobial action of azelaic acid and a direct influence on follicular hyperkeratosis are assumed to be the basis for the therapeutic efficacy of Skinoren gel in acne.Clinically, a significant reduction in the colonisation density of Propionibacterium acnes and a significant reduction in the fraction of free fatty acids in the skin surface lipids is observed.In vitro and in vivo, azelaic acid inhibits the proliferation of keratinocytes and normalises the disturbed terminal epidermal differentiation processes in acne. In the rabbit ear model azelaic acid accelerates the comedolysis of tetradecane-induced comedones.The mechanism by which azelaic acid interferes with the pathogenic events in rosacea is unknown. Several in vitro and ex vivo investigations indicate that azelaic acid may exert an anti-inflammatory effect by reducing the formation of pro-inflammatory, reactive oxygen species.Pharmacokinetic properties:Azelaic acid penetrates into all layers of the skin after topical application of the gel. Penetration is faster into damaged skin than into intact skin. A total of 3,6 % of the dose applied is absorbed percutaneously after a single topical application of 1 g azelaic acid (5g Skinoren acne acne cream). Clinical investigations in acne patients indicated similar absorption rates of azelaic acid from Skinoren gel and cream.A portion of the azelaic acid absorbed through the skin is excreted in unchanged form with the urine. The remaining portion is broken down by β-oxidation into dicarboxylic acids with shorter chain length (C7, C5) which have likewise been found in the urine.Steady-state plasma levels of azelaic acid in rosacea patients after 8 weeks twice daily treatment with Skinoren gel were double those seen in control patients. However the plasma levels were within the range also observed in volunteers and acne patients on normal diets. This indicates that the extent of percutaneous absorption of azelaic acid following twice daily application of Skinoren gel does not alter the systemic burden of azelaic acid derived from dietary and endogenous sources.Indications:Treatment of mild to moderate acne vulgaris.Treatment of mild to moderate (papulopustular) rosacea.Identification:White to yellowish white opaque hydrogel.Presentation:Standard tubes with membrane closures and screw caps (tube material aluminium, internal coating done with epoxide, end seal band made of polyamide-based compound, external coating made of polyester, screw cap made of high density polyethylene) containing 5g or 30g or 50g.Patient information leaflet:Scheduling status of the medicinal product:Name of the medicinal product:Skinoren gel.Gel.What Skinoren gel is used for:Skinoren gel is used for the treatment of mild to moderate acne vulgaris and mild to moderate (papulopustular) rosacea.Presentation of Skinoren gel:Standard tubes with membrane closures and screw caps (tube material aluminium, internal coating done with epoxide, end sea (band made of polyamide-based compound, external, coating made of polyester, screw cap made of high density polyethylene) containing 5g or 30g or 50g.Identification of Skinoren gel:White to yellowish white opaque hydrogel.

Pack size:
30g

Quantity in pack:
1

Marketing description:
S1 Skinoren®.Gel.Bayer.15%.30g.

Brand:
Skinoren

Package type:
Pack

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Usage instructions:
Dosage and directions for use:Skinoren gel should be applied to the affected areas of the skin twice a day (morning and evening) and rubbed in gently. Approximately 0,5 g = 2,5 cm of gel is sufficient for the entire facial area.Before Skinoren gel is applied, the skin should be thoroughly cleaned with plain water, and dried. A mild skin-cleansing agent may be used. It is important to use Skinoren gel continuously over the entire period of treatment.The duration of use of Skinoren gel can vary from person to person and also depends on the severity of the skin disorder. In general, an improvement becomes apparent after about 4 weeks. To obtain the best results, however, Skinoren gel should be used continuously over several months.In the event of intolerable skin irritation (see "side effects"), the amount of gel per application should be reduced or the frequency of use of Skinoren gel should be reduced to once a day until the irritation ceases. If required, the treatment should be temporarily interrupted for a few days.Paediatric population:Used in adolescents (12 to 18 years of age) for the treatment of acne vulgaris. Dose adjustment is not required when Skinoren gel is administered to adolescents (12 to 18 years of age).The safety and efficacy of Skinoren gel for the treatment acne vulgaris in children below the age of 12 years have not been established.The safety and efficacy of Skinoren gel for the treatment of papulopustular rosacea in children below the age of 18 years have not been established.Patient information leaflet:Please read this leaflet carefully before you start using Skinoren gel.Keep this leaflet. You may need to read it again.If you have further questions, please ask your doctor or your pharmacist.Skinoren gel has been prescribed for you personally and you should not share your medicine with other people. It may harm them, even if their symptoms are the same as yours.How to use Skinoren gel:Do not share medicines prescribed for you with others.Skinoren gel should be applied to the affected area of the skin twice a day (morning and evening) and rubbed in gently.Approximately 0.5g = 2.5 cm of gel is sufficient for the entire facial area.Before Skinoren gel is applied, the skin should be thoroughly cleaned with plain water and dried. A mild skin-cleansing agent may be used.It is important to use Skinoren gel continuously over the entire period of treatment.The duration of use of Skinoren gel can vary from person to person and also depends on the severity of the skin disorder. In general, an improvement becomes apparent after about 4 weeks.To obtain the best results, however, Skinoren gel should be used continuously over several months.In the event of intolerable skin irritation (see "side effects"), the amount of gel per application should be reduced or the frequency of use of Skinoren gel should be reduced to once a day until the irritation cases. If required, the treatment should be temporarily interrupted for a few days.Paediatric population:Skinoren gel is used in adolescents (12 to 18 years of age) for the treatment of acne vulgaris. No dose adjustment is required.Safety and efficacy of Skinoren gel for the treatment of acne vulgaris in children below the age of 12 years have not been established.The safety and efficacy of Skinoren gel for the treatment of papulopustular rosacea in children below the age of 18 years have not been established.

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Ingredients:
What Skinoren gel contains:1 gram Skinoren Gel Contains 150mg Azelaic Acid Active Ingredient.The other ingredients are: Propylene Glycol Polysorbate 80, Lecithin, Carbopol 980, Triglycerides: Medium Chain, Sodium Hydroxide, Disodium Edentate, Benzoic Acid and Purified Water.

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